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KMID : 1123920150290010033
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Korean Journal of Oriental Physiology and Pathology
2015 Volume.29 No. 1 p.33 ~ p.38
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Inhibitory Effects of Black currant seed oil on 2,4-Dinitrochlorobenzene Induced Atopic Dermatitis in BALB/c Mice Model
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Lee Ye-Seo
Park Kyo-Hyun
Kim Bae-Hwan
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Abstract
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This study investigated the clinical parameters of atopic dermatitis and evaluated the inhibitory effects of Black currant seed oil for atopic dermatitis by using a Dinitrochlorobenzene(DNCB) induced BALB/c mice model. Five-week-old BALB/c mice were divided into four groups: normal group (N, non-treated), control group (C, atopic dermatitis-induced), positive control group (PC, Tacrolimus ointment-treated against induced atopic dermatitis, PC), experiment group (E, Black currant seed oil-treated against induced atopic dermatitis). After induction of atopic dermatitis by DNCB, the erythema, edema, eschar, and scratching were severely observed. The symptoms of atopic dermatitis were improved after 2 weeks, and almost disappeared after 4 weeks in PC and E group. The increased frequencies of scratching in C group were decreased in PC and E group. Transepidermal water loss, erythema index and serum IgE level were significantly decreased in E and PC compared to that in C after 4 weeks of the treatment. The results indicated that Black currant seed oil can relieve atopic dermatitis symptoms effectively, and may be possibly used as a functional material for suppression of atopic dermatitis.
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KEYWORD
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Black currant seed oil, atopic dermatitis, BALB/c mice, DNCB
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